临床研究FSH高水平与卵子和胚胎的数量、质量及

2011;31(5) 南方医科大学学报（J South Med Univ ） ·777 ·

·临床研究·年轻妇女基础FSH 高水平与卵子和胚胎的数量、质量及临床结局的关系陈士岭，罗燕群，夏 容，陈 薪，施晓鋆，郑海燕，王乐乐，吴雅琴南方医科大学南方医院妇产科生殖医学中心，广东 广州 510515摘要：目的探讨小于35周岁不孕妇女的基础卵泡刺激素（FSH）升高是否影响卵子和胚胎的数量、质量及其临床结局。方法 回顾性分析294 个年龄<35 周岁的体外受精胚胎移植治疗周期，按基础FSH 水平分A 组(10~ 14.99 U/L ）、B 组(15~19.99 U/L ）和C 组(FSH≥20 U/L) ，比较获卵数、卵子和胚胎的形态学、临床结局等指标的差异。结果 B 组和C 组的获卵数、总胚胎数和优质胚胎数较A 组低，促性腺激素总量较A 组高；三组间成熟卵子率、卵裂球数目比例、正常受精率、卵裂率、优质胚胎率、种植率、临床妊娠率、活产率和早 期流产率差异无统计学意义，基础FSH≥15 U/L 妇女的临床妊娠率和活产率有降低的趋势。结论 小于35 岁不孕妇女随基础FSH 升高，尤其≥15 U/L 者，卵巢储备功能减退，卵子数和胚胎数明显减少，但卵子和胚胎质量未受影响，仍能获得相当好的临床妊娠率。关键词：基础FSH ；胚胎质量；体外受精胚胎移植中图分类号：R711.6 文献标志码：A 文章编号：16734254（2011）05077705Impact of elevated basal folliclestimulating hormone on the quantity and quality ofoocytes and embryos and pregnancy outcomes in young womenCHEN Shiling, LUO Yanqun, XIA Rong, CHEN Xin, SHI Xiaoyun, ZHENG Haiyan, WANG Lele, WU YaqinCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University,Guangzhou 510515, ChinaAbstract: Objective To evaluate the effect of elevated basal folliclestimulating hormone (FSH) on both the quantityand quality of oocytes and embryos and the clinical outcomes of pregnancy in women under 35 years of age. MethodsA retrospective analysis was conducted for inspecting 294 in vitro fertilizationembryo transfer (IVFET) cycles inwomen under 35 years of age. According to the basal FSH levels, the women were divided into groups A, B, and Cwith basal FSH of 1014.99, 1519.99 and ≥20 IU/L, respectively, to compare the average number of oocytes retrieved,morphologies of the oocytes